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Wednesday, May 13, 2020 | History

2 edition of effects of hexachlorophene on mitochondrial and artificial membrane systems found in the catalog.

effects of hexachlorophene on mitochondrial and artificial membrane systems

Donald Allen Ramberg

effects of hexachlorophene on mitochondrial and artificial membrane systems

by Donald Allen Ramberg

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  • 38 Currently reading

Published .
Written in English

    Subjects:
  • Hexachlorophene.

  • Edition Notes

    Statementby Donald Allen Ramberg.
    The Physical Object
    Pagination300 leaves, bound :
    Number of Pages300
    ID Numbers
    Open LibraryOL14233719M

    High concentrations of ammonia are toxic for organisms as they can cause severe detrimental effects on the central nervous system and can lead to intra-as well as extra-cellular acid-base. Environmental Health Active Ingredient System Effect Temperature Fluctuation Reproductive System These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

      At the same time, the loss of mitochondrial respiratory competence, and reduced intracellular ATP levels, might result in rupture of the plasma membrane and necrotic cell death Cited by: The plasma membrane and other membranes of the cell are composed mostly of lipids and proteins. Phospholipid-dietary fats but have only two fatty acid tails instead of three. Phospholipid biplayer-two layered membrane material. Fluid mosaic-fluid because the molecules can move freely past one another and a mosaic because of the diversity of.

    Figure 1. The electron transport chain is a series of electron transporters embedded in the inner mitochondrial membrane that shuttles electrons from NADH and FADH 2 to molecular oxygen. In the process, protons are pumped from the mitochondrial matrix to the intermembrane space, and oxygen is reduced to form water.   The effect of membrane cholesterol content on ion transport processes in plasma membranes Bastiaanse. Department of Cardiology, University Hospital, Building 1, C5-P24, Rijnsburger AA Leiden, Netherlands is a useful membrane system to investigate the influence of cholesterol on intrinsic membrane by:


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Effects of hexachlorophene on mitochondrial and artificial membrane systems by Donald Allen Ramberg Download PDF EPUB FB2

The work in this thesis was designed to investigate the effects of HCP on mitochondrial membranes, lipid vesicles, and lipid bilayer membranes and their relation to the above toxic effects. HCP was found to bind to sonicated lecithin vesicles as if bound in a hydrophobic environment as demonstrated by UV difference : Donald Allen Ramberg.

The effects of hexachlorophene on mitochondrial and artificial membrane systems The work in this thesis was designed to investigate the\ud effects of HCP on mitochondrial membranes, lipid vesicles, and lipid\ud bilayer membranes and their relation to the above toxic effects.\ud HCP was found to bind to sonicated lecithin vesicles as if.

The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application.

Here we examined the effects of HCP on murine Cited by: 4. Abstract. Hexachlorophene is a soap-compatible bisphenol that has been widely used as an antiseptic, yet its mechanism of action is undefined.

The relative threshold concentration for bactericidal effect on a susceptible test organism, Bacillus megaterium, was established to be about 10 μg/mg of cell dry this or at high (≥ μg/mg) concentration, adsorptive uptake by cells Cited by: Effect of mitochondrial and plasma membrane potentials on accumulation of hexakais (2-methoxybutylisonitrile) technetium (I) in cultured mouse fibroblasts.

The glucose dependence of the antiapoptotic effects of growth factors and Akt plus a strong correlation between Akt-regulated mitochondrial hexokinase Cited by: Accordingly, to provide an indication of their ability to perturb mammalian membranes, we have studied the effect of halogenated antibacterials on the erythrocyte membrane in vitro as a model.

The halo- genated antibacterials were found to induce hemolysis and K÷ efflux under isotonic conditions and to protect against hypotonic by: 7. Aβ42 Double Mutant Inhibits AβInduced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells Ofek Oren Shani Ben Zichri.

Isolation of Mitochondria from Cells and Tissues stabilize the nuclear membrane, omit washing the mitochondrial pellet, omit any density gradient Isolation of Mitochondria from Cells and Tissues This is a free sample of content from Subcellular Fractionation.

across mitochondrial membranes than they are in transporting protons across conventional Mueller-Rudin types of artificial bilayers. The second observation is. Destabilization of plasma and inner mitochondrial membranes by extra- and intracellular amyloid β peptide (Aβ42) aggregates may lead to dysregulated calcium flux through the plasma membrane, mitochondrial-mediated apoptosis, and neuronal cell death in patients with Alzheimer’s disease.

In the current study, experiments performed with artificial membranes, isolated mitochondria, and Author: Ofek Oren, Shani Ben Zichri, Ran Taube, Raz Jelinek, Niv Papo. The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme creatine kinase (CK) and its high-energy product phosphocreatine (PCr).

Multidisciplinary studies have established molecular, cellular, organ and somatic functions of the CK/PCr system, in particular for cells and tissues with high and intermittent energy by:   The effects of diphenyleneiodonium and of 2,4-dichlorodiphenyleneiodonium on mitochondrial reactions.

Mechanism of the inhibition of oxygen uptake as a consequence of the catalysis of the chloride/hydroxyl-ion by: Mitochondrial membrane permeabilization (MMP) is a key event of apoptotic cell death associated with the release of caspase activators and caspase-independent death effectors from the intermembrane space, dissipation of the inner mitochondrial transmembrane potential (ΔΨ m), and a perturbation of oxidative phosphorylation 1,2,3,4,5,6,- and antiapoptotic members of the Bcl-2 family Cited by: Hexachlorophene, also known as Nabac, is an organochlorine compound that was once widely used as a compound occurs as a white odorless solid, although commercial samples can be off-white and possess a slightly phenolic odor.

It is insoluble in water but dissolves in acetone, ethanol, diethyl ether, and medicine, hexachlorophene is useful as a topical anti Legal status: US: ℞-only for human use, Rx-only. Experimental studies with erythrocyte membranes show that hexachlorophene binds to cell membranes, resulting in the loss of ion gradients across the membrane.

It is possible that hexachlorophene causes the loss of the ability to exclude ions from between layers of myelin, and that, with ion entry, water also separates the myelin layers, forming edema.

The effects of HCO3- on mitochondrial respiration are reported and discussed. Full text. Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article(K), or click on a page image below to browse page by by:   Finally, several groups including McKallip et al.

22 Ryan et al. 15 and Mato et al. 39 reported interactions of CBD with mitochondrial targets as evidenced by its effects on mitochondrial membrane potential, ROS production, and changes in calcium ion homeostasis.

We therefore tested the effect of cyclosporin A (Cys A), a blocker of the Cited by:   What are some other side effects of Hexachlorophene. All drugs may cause side effects. However, many people have no side effects or only have minor side effects.

Call your doctor or get medical help if any of these side effects or any other side effects /   However, the ability of synuclein to interact with artificial membranes in vitro depends on a high lipid:protein ratio, and the content of acidic phospholipid (mostly cardiolipin) in mitochondrial membranes may exceed that of other organelles (80–83).

The specific effects of synuclein on mitochondrial morphology may thus simply reflect the unusually high concentration of acidic Cited by:. The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase.

It induces leakage, causes protoplast lysis, and inhibits respiration.Mitochondrial disease can affect the brain, heart, liver, skeletal muscles, kidney, endocrine system and respiratory systems. The symptoms within these systems are diverse and may be due to a number of different defects within the mitochondria 1,5.

Medicines can affect many of the different functions within the mitochondria.Issue: Feb Reverse Mitochondrial Damage. Age-related deterioration of the mitochondria in our cells is associated with an array of deadly conditions, ranging from senility to diabetes and heart failure.

Researchers have recently discovered that this deadly process can be reversed with cellular energizers that help restore and preserve mitochondrial function.